Rhythmic Contractions And Relaxation Of Isolated Gut

Rhythmic Contractions And Relaxation Of Isolated Gut The isolated gut has a spontaneous activity with rhythmic contractions and relaxation of its smooth muscles. Various drugs that affect the smooth muscles by either direct or indirect stimulation were used (Day Vane 1963). These drugs were acetylcholine, atropine, adrenaline, noradrenaline and d-tubocurarine. Acetylcholine is a neurotransmitter (Martini 2009, p. 304) that is released by a neuron and acts directly on the plasma membrane of another cell, in this case smooth muscles. It affects both the muscarinic and nicotinic receptors located on the smooth muscle membrane (Broadley Kelly 2001). The effects of acetylcholine on the muscarinic receptors can be identified by another drug, atropine (Broadley Kelly 2001). Atropine is an alkaloid found in several plants (Broadley Kelly 2001) and inhibits binding of acetylcholine to post synaptic membrane of smooth muscle cells (Martini 2009, p. 425). Adrenaline and noradrenaline are hormones released from the suprarenal glands and induce relaxation of the smooth muscles by binding to the adrenergic receptors. They are called catecholamines because of their structure (shown in figure 1). D-tubocurarine is an alkaloid drug derived from curare and is a neuromuscular nicotinic receptor antagonist1. It prevents acetylcholine from binding to the postsynaptic membrane of muscle fibres (martini 2009, p. 425). AIM The aim of this experiment was to investigate the effects of acetylcholine, atropine, adrenaline, noradrenaline and d-tubocurarine on the smooth muscles of the gut. MATERIALS AND METHODS Materials Transducer Heater Heat exchanger chart recorder experimental tissue (rat intestine) organ bath with carbogen-bubbled Krebs Henseleit solution at 37ËÅ ¡C drugs used in the experiment were: 1 mg/mL acetylcholine 1 mg/mL atropine 1 g/mL adrenaline 1mg/mL noradrenaline 1 mg/mL d-tubocurarine Methods At the start of the experiment, the transducer was calibrated using weights to allow conversion of the amount of displacement of the intestine into electrical signals which are then recorded. The amount of movement measured corresponds to the type of drug added. The experimental rat tissue that was dissected previously was supported in a 100 mL organ bath containing carbogen-bubbled Krebs Henseleit solution at 37ËÅ ¡C aerated with a mixture of 95% oxygen and 5% carbon dioxide. The tissue was anchored to the device that applied force to stretch the muscle until a steady rate of contraction was obtained. The force of contraction was then measured and converted to electrical signals which were recorded by the chart recorder. Some equilibration time was allowed for the preparation to stabilise its activity in the organ bath before starting the experiment. The smooth muscles of the tissue had spontaneous activity before the administration of any drug. The exact concentration and volu me of the drugs administered were then calculated to obtain the right concentration. A volume of 0.1ml of 1mg/mL of acetylcholine was first administered to the muscles and its effects were recorded. The organ bath was drained and refilled so as to resume its baseline activity. Three increments of 0.025 ml of 1mg/mL atropine were added to the organ bath periodically to see its effect on the smooth muscles. Another dose of 0.5 mL of 1mg/mL acetylcholine was added into the organ bath without draining and refilling. The effects were then observed on the chart recorder. The organ bath was drained and refilled again. 0.1mL of 1gm/mL adrenaline was added to the water bath. The organ bath was again drained and refilled. 0.1mL of 1mg/ml noradrenaline was added to the organ bath. The organ bath was again drained and refilled. 0.5mL of 1mg/mL acetylcholine was added and the effects were observed. The organ bath was again drained and refilled. 0.025 mL of 1 mg/mL d-tubocurarine was added to the water bath and the effects were recorded. Lastly without draining the organ bath, two increments of 0.5ml of 1mg/mL of acetylcholine was added at regular intervals and its effect was recorded. RESULTS Calculation of the volume of the drugs used: acetylcholine Original concentration C:Documents and Settings7168241Local SettingsTemporary Internet FilesContent.Word22032011079.jpg Figure 1: Experiment setup Table 1: Effect of the drugs administered on the smooth muscles of the gut Drug administered Effect on smooth muscle observed. Acetylcholine Increase in contraction rate Conductance and amplitude increased Atropine Decrease in contraction rate- muscle relaxes Decrease in amplitude, tone and frequency Adrenaline Large decrease in amplitude Effect was very strong ( alpha and beta receptors on smooth muscles) Noradrenaline Small decrease in amplitude ( it has alpha receptors) Acetylcholine Increase in contraction rate Conductance and amplitude increased D-tubocurarine No effect as the muscle tone remained constant Acetylcholine Increase in contraction rate Conductance and large increase in amplitude when first dose was added and slight decrease in the amplitude when second dose was added DISCUSSION The muscle had spontaneous activity before the addition of the drugs. They were self excitatory and depolarized without the addition of any drugs. WHY As observed in table 1, acetylcholine increased the rate of contraction in the smooth muscles. Acetylcholine is a neurotransmitter released at the neurojunction of the nerve and the smooth muscles. Contraction of the smooth muscle achieved is due to acetylcholines effect on membrane permeability via the second messengers since it cant enter the cells interior. Acetylcholine binds to the muscarinic receptors and causes GTP binding to the alpha subunit of the G-protein. The GTP-bound alpha subunit activates the production of the second messengers by activating phosphoinosidase C (PIC). PIC hydrolyses phosphatidylinositol 4, 5-biphosphate which then forms inositol 1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG). IP3 and DAG bind to the receptors on the sarcoplasm reticulum and cause the release of calcium ions into the intracellular f luid to initiate contraction of the muscle (Broadley Kelly 2001). Acetylcholine also causes the contraction of the smooth muscles by depolarizing the membrane directly via the nicotinic receptors. As seen in the table 1, adding atropine to the water bath caused decrease in the amplitude of the stimulus. This is due to the fact that atropine is a reversible competitive antagonist for acetylcholine at the muscarinic receptors. It has no effect on its binding on nicotinic receptors (Evers Maze 2004). It prevents acetylcholine that has built up at the neuromuscular junction from binding to the receptors and depolarizing the post synaptic membrane thus preventing the generation of an impulse in the cell. Acetylcholine produces a response when it binds to the receptors whereas atropine binds to the same receptors as acetylcholine without producing a response. It just makes the receptors unavailable for acetylcholine (Abel 1974, p.106). When another dose of acetylcholine was added to the water bath, the amplitude is seen increasing to a lower intensity than before atropine was added and transmission is restored and the muscle begins to contract. This is due to the fact that this new dose of acetylcholine displaces atropine from the receptors since it is a reversible antagonist. When adrenaline was added to the organ bath, the amplitude dropped by a large amount due to its combination with alpha and beta receptors on the smooth muscle. When noradrenaline was administered, the amplitude decreased was a small amount compared to the large drop in adrenaline. This small response obtained due to addition of noradrenaline is due to its sensitivity to alpha receptors only. Combination of noradrenaline with alpha receptors increases the K efflux and influx in depolarized smooth muscle (Bulbring 1970, p.286). This increase in K conductance caused an increase in membrane permeability and inhibited depolarization. Adrenaline caused the relaxation of the smooth muscles coupled with hyperpolarization of the membrane as a result of increase of potassium ions. The action of the sympathetic transmitters; adrenaline and noradrenaline involved direct action via the alpha and bet a receptors (Paton Vizi 1969). Acetylcholine added again resulted in high increase in the amplitude, which decreased gradually. D-tubocurarine added to the organ bath had no effect on the contraction of the muscle as it maintained a constant tone. Lastly the acetylcholine added resulted in an increase in the amplitude. This observation agreed with the expected result. It was expected for the amplitude to be constant since there wasnt any acetylcholine in the organ bath for d-tubocurarine to replace. A spike in the amplitude was observed when acetylcholine was added. Acetylcholine replaced d-tubocurarine from the nicotinic receptors and restores the transmission of the stimulus2. This shows that the neuromuscular transmission block produced by d-tubocurarine is abolished when acetylcholine is added (Bradley 1989, p.47). CONCLUSION It was found that both adrenaline and noradrenaline affect the smooth muscles via alpha and beta receptors and produce a similar effect that is relaxation. Adrenaline is more potent than noradrenaline since it utilizes both alpha and beta receptors while the other one only affects beta receptors. Acetylcholine is an excitatory neurotransmitter that causes contraction of smooth muscles via both nicotinic and muscarinic receptors. Atropine is a competitive antagonist of acetylcholine on the muscarinic receptors. D-tubocurarine is a mu

25th Hour Movie Analysis Essay

1. 25th Hour, directed by Spike Lee, presents men partially in a typical way. The typical representation of men in Hollywood film defines them as being aggressive and powerful. They are expected to bear pain silently, suppress their emotions easily, and dominate their women. Also, typical males usually don’t pay any attention to their sicknesses and try to prove their masculinity to others. However, the movie includes a hegemonic negotiation of emotional outbursts over the traditional image of masculinity. Therefore, the main character, Monty, is a famous and respected drug dealer who spends his last day of freedom. He is presented as being powerful throughout the movie because he was living the American dream, driving an expensive car, owning a fancy apartment, having a beautiful, exotic girlfriend and hanging out in luxurious clubs. Although he is independent, being a provider for Naturelle and living an expensive life, he depends on drugs to maintain his power. Monty’s apartment has hardwood floors and tall windows facing the brownstones across the street. There are some black-and-white photographs, lining the walls, and the largest photo, hanging above the sofa, represents Brogan’s Bar; the design of Monty’s apartment shows his power and wealth that came from drugs. Monty’s costuming and appearance illustrate his classy personality. His black and shiny shoes, sober and dark clothes, stylish and well-groomed hair reflect his past glamorous and wealthy life. Although Monty is going to prison in 24 hours, he suppresses all his emotions and sufferings. He walks slowly with Doyle, his dog, and reflects quietly on his life. The length of these shots is around fifteen seconds and shows his masculine insensitivity for the last day of his freedom. When he goes to the Coventry Preparatory School, he looks at his team picture smiling at his past happy memories. Monty goes to talk to Jacob about a change of plans as nothing has happened; he is very calm and doesn’t show any emotion. He even notices Mary saying that she looks cute. Monty tries to pretend that everything is fine, being indifferent and not affected by his imprisonment. Also when Naturelle asks him to talk to her, he answers as if there is nothing to talk about. Montgomery tries to show that he is emotionally powerful to overcome his fear of going to prison. Moreover, when Frank beats Monty, the latter ignores his pain and doesn’t even want to go to the doctor. He is getting prepared mentally and suffers in silence, as he would have to endure prison pain without complaint. Additionally, the traditional male expects to control females, and Montgomery dominates Naturelle throughout the movie. For example, when Montgomery comes home and they walk on the stairs he walks first and Naturelle follows him. He is in a dominant position and the woman just follows and listens to his concerns. Throughout Naturelle and Monty’s conversation Monty is shown in low camera angles, which present his power and control over his girlfriend. On the other hand, Monty shows indifference to people but inside he is furious and terrified. The hegemonic negotiation of traditional masculinity is presented because Monty also shows some emotional breakdowns showing his weakness and powerlessness. This is a more modern representation of masculinity similar to 1950s American films. There are several film form elements that present men as being weak. Monty doesn’t emulate his father but he follows his masculine instinct. The music emphasizes the hidden emotions and feelings of Monty and of other characters affected by his imprisonment. The music provides a very powerful perception of anger, fury, regret, and sorrow. It is in perfect equilibrium to Monty’s inner feelings. For example, from the opening scene the music played represents tension and sorrow and although the tempo changes constantly it is still in relation to Monty’s reactions and emotions of his last day of freedom. After the opening scene, Monty is sitting with his dog getting harassed by a drug addict; the mise en scene of this scene illustrating Monty behind bars foreshadows his future as being lonely, sad and weak. The high camera angles of Monty show him as fragile, humble and vulnerable. The depressing, gloomy and dark weather accentuates his vulnerability. Also, although he is dominant over Naturelle he cares about her future and tells her to forget about him. His strong, exterior armor is cracked by his emotional outbreak during Monty’s washroom monologue. In a collage of over-exposed images of different stereotype people, Monty curses and blames every group, and race for his downfall and for his wealth greed. More importantly he curses himself saying:† No, fuck you Montgomery Brogan† (25th Hour). He finally understands that it is not the society that is accountable for his actions but he is, and it is time for him to pay for the choices he made throughout his life. Therefore, this scene reveals his sensitivity and emotional pain. It presents how love for life can flip into hate. The dark light and self- reflection of Monty resent his inner fury that is ready to explode, while the intense music highlights Monty’s personal rage. Therefore, there’s a bright and heroic strength to Monty, together with a charismatic and sympathetic side, but also a quiet desperation and sorrow in Monty’s last hours of freedom. Monty’s friend, Jacob is presented as a simple teacher that has a crush on his rebellious teenager. He is unable to cope with his feelings. His character is a hegemonic negotiation of traditional masculinity because he is afraid of being judged for his feelings. He acts passively and seems weak in front of females. He is emotional and humble in front of Mary; but he is white so he doesn’t challenge the patriarchal dominance. High camera angles of Jacob show his inferiority and humbleness over other characters. His poor costuming represents his simple personality because he feels guilty for being born rich. When the bell rings and the class lecture is over, Jacob remains alone; a close up of his face show his deep emotions. In the teacher’s lounge scene, Jacob is presented as being stressed and unable to take control over his life. His glasses represent intelligence and rationality, as the typical representation of male. Jacob is afraid of expressing his feelings, so he is lying his friend Frank about his feelings for Mary, saying that Terry a colleague professor likes her. He even tries to make a good impression over Mary stating that he likes a young DJ. In the club Jacob can’t resist Mary’s seductions and he kisses her. The red lights accentuate the danger Jacob is going through. He acts frantically and the mixed song â€Å"but it’s alright â€Å" highlights Jacob’s feelings. He made the choice of kissing her, and his choice will be reflected throughout his life. On the other hand, Frank represents the typical representation of men. He is rich, powerful and successful. He works as a Wall Street stockbroker and is ready to take risk in order to achieve success. His costuming and makeup present him as a male that cares about his appearance and tries to create an impression on people. The mise en scene of his work environment presents a very busy, stressing and hectic workplace but in order to succeed he has to endure the hardship. When he talks to Jacob about Monty’s imprisonment he is very hard on Monty but realistic. He says that the friendship with Montgomery will end after that night; the music, the dark setting and visualization of the devastating Ground Zero depict the cruel reality. Some close ups of Frank portray his emotions and guilt concerning Montgomery’s prison years. Frank tries to make Naturelle feel guilty but doesn’t take into account his mistakes of not helping Monty. As other typical male who throw the guilt to everyone else except himself.  Therefore, throughout the movie males are represented in a typical Hollywood way but Spike Lee introduces a hegemonic negotiation where men appear more sensitive, emotional and vulnerable. 2. In the film 25th Hour, female’s representation is stereotypical. Naturelle, Monty’s girlfriend, is presented as the beautiful, loyal and exotic girlfriend. Naturelle might be considered the femme fatale being smart and sexy. Her smartness is reflected in the scene where she is waiting for Monty to come home, she is reading a book; so she is not as naive as people consider her. At the beginning, male characters think that she is the traitor, so she represents a threat for men. Monty has doubts and trust issues towards Naturelle because she knew where the drugs were. However, in the end Naturelle wasn’t the traitor, wasn’t the woman that destroyed the man that provided for her, instead it was Monty’s bodyguard. It turns out that Naturelle’s loyalty and love is genuine, as one of a housewife. When Montgomery comes home from his long walk, he finds out that Naturelle waited for him the whole day, which shows her concern for Monty’s life. She kisses him first and shows her care and affection throughout the movie. While Naturelle and Monty walk inside the apartment, Monty lies down on the couch whereas Naturelle goes first to kitchen, as a feminine instinct. Her fragility is shown when she tries to open the honey jar. Eating raw honey suggests that she is actually sweet and tender. Close ups of Naturelle deepen her emotions and feelings about Montgomery; and in the bathroom scene Naturelle expresses her love and happiness while being with Monty. Her Puerto Rican tattoo shows that although her boyfriend, who was providing for her didn’t agree with the tattoo, she still got it; her action shows her sense of independence while being faithful to her man. Throughout the movie, fetishization of Naturelle’s body occurs. During the bathroom scene, her legs are being fetishized while in the club close ups of her breasts accentuate her sexy curves. The men around her, such as Frank, always admire her; and her costuming and makeup emphasize her sexy figure. She is dressed in short, sexy, red, silver dresses that make her look powerful and sexy. During a flashback of Monty, when he remembers how he met Naturelle, she appears very sweet, innocent, young and with a provocative skirt. Monty admits that Naturelle is the only girl that he slept with and he keeps fantasizing about her. This demonstrates that she is a source of temptation and happiness for Monty. It is happiness because even in his illusionary ending Naturelle is the mother of his kids and he would have a happy life with her. On the other hand, Mary, the young student, is presented as a moist, innocent but tempting girl. She might also be presented as a femme fatale because she represents a threat for the professor. She is smart enough to argue for her marks. She uses her sexiness to make Jacob weak. Her makeup, costuming and tattoo present her as a rebellious and independent woman. She is independent because she fights for her opinions; for example she came to argue about the fairness of her mark. She is playful and tries to seduce her professor. Also, while she was reading a play in the class, Mary is shot in low angle while the professor in high angle; this implies that Mary controls Jacob through her sexiness and Jacob appears as weak and unable to defend himself from Mary’s seductive allure. However, Mary is still innocent because when Jacob goes to kiss her she has her eyes closed waiting for him, this show her inexperience and fragility. Fetishization of her legs and waist appears and Jacob is tempted by it. Therefore, women appear as a source of temptation for the actors and, their representation is stereotypical; Naturelle’s representation implies love and affection for her boyfriend whereas Mary’s representation presents a rebellious and provocative spirit. 3. Hero or victim, there’s no one to blame or honor for our actions than ourselves.  Each person has to take responsibility and hopefully survive the hard life trials. In 25th Hour, the protagonist has to be accountable for his own actions and not blame others for his imprisonment. All the viewers could relate to Montgomery’s situation because at one point we all have to pay for our mistakes even though it mentally destroys us; but we have to be able to isolate the cruel reality from the beauty of living a dream. The film opens with a black sky and two beams of light, which come from where the twin towers used to be. World Trade Center is presented as Ground Zero, an empty, devastating and ghostly space. This empty space reflects the future of Monty’s life because even though he had everything he threw it away, therefore he is responsible for neglecting what he owned. The music creates a more dramatic and mysterious effect. The viewers are expected to act sympathetically to Monty because although he did not perform heroic deeds, he expresses sincerely his feelings. The ending of the movie is as illusionary as Montgomery’s social power; it lasts till the reality takes over. Also, Monty’s father describes the happy and humble life Monty would have if he would not go to prison and run away. It is an illusionary representation of the typical Hollywood end living happily the American Dream. However, it’s just a dream and Montgomery takes responsibility for his actions because he cannot hide or blame others for what he did. Also, the director presents Monty in a smart way as being able to survive in prison, to become enlightened and who knows maybe after seven years to start an honest and simple life. The audience is given the choice of offering to the hero, a second chance, as he offered one to Doyle, his loving dog. The film ends with a road, which suggests that Monty’s life paths depend only on him. Although the weather creates a melancholic state, the presence of green trees symbolizes Monty’s rebirth. Therefore, there is still hope for Monty after he takes responsibility for his life choices. The ending of the movie makes us feel reflective because we start to contemplate over what is wrong or right in life, over what we should praise or value and that we are all heroes and victims, but is our individual choice that makes us distinctive.

Importance Of Human Resource Department ( Hrm ) At Tesco

Introduction This essay will discuss the key theories and principles relating to recruitment and selection, personality and also motivation to ensure Tesco brings success to their business operations. Tesco is a multi-national organisation; it has 13 supermarkets in different countries around the globe including India, Slovakia, Poland, Hungary, China and also Turkey. Therefore, this includes 2,318 stores worldwide and 1,878 stores in the UK. The scale of this multi-national organisational is very large due to the amount of stores, as well as having more than 310,000 employees in the UK and 500,000 globally. Over the years, Tesco is recognised as one of the largest retailers in the world in terms of profitability and also revenues. The importance of human resource department (HRM) at Tesco is to â€Å"help in achieving organisational goals with effectiveness and efficiency, provide maximum opportunity for personnel development, providing suitable and most productive employment and also motivate individuals in their work†. (Shivarudrappa, Ramachandra, Gopalakrishna, 2010). This highlights that HRM is one of the key departments within any organisations including Tesco because it consists numerous of significant actions contributed in the hiring, recruiting, interviewing, training, measuring and monitoring performance within the organisation and also developing all kinds of possible and current employees. In addition, a constructive HRM strategy may increase the performance ofShow MoreRelatedDifferentiate Between Personnel Management And Human Resource Management1500 Words   |  6 Pages1.1. 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Table of Contents Introduction†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Read MoreAn Assignment On Human Resource Management8731 Words   |  35 Pages AA Hamilton College HND in Business Unit 21: HUMAN RESOURCE MANAGEMENT Submitted by: Name: Ana Maria Vasile Group: B9 ID: 23243 This assignment focus on analyzing human resource management in two companies: Tesco and Sainsbury which are in retail industry. It will highlight key area: human resource management, motivation, employment low. 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Human Resource Management is one aspect within Project management that plays a significant role. Tesco PLC has become one of the leading retailers in the UK, as well as worldwide over the years. Founded by Jack Cohen in 1919, he began selling groceries from a stallRead MoreHuman Resource Management Essay3492 Words   |  14 PagesIntroduction Working in corporation or large companies is very popular nowadays because large companies are often with the large scale, huge capital and professional operation. Human resource has significant role in the organization. Human resource management is concerned with the people dimensions in management. Since every organization is made up of people, acquiring their services, developing their skills, motivating them to high level of performance, and ensuring that they continue to maintain

Sir Phillip Sidneys Sonnet #47 from Astrophil and Stella...

Sir Phillip Sidneys Sonnet #47 from Astrophil and Stella Sir Phillip Sidneys Sonnet # 47 from Astrophil and Stella The sonnet is a short concise form of writing and it takes a great mind to master it. By mastering it, I mean to be able to say so much in what seems like so little space. Sir Phillip Sidney comes as close to mastering it as anyone else in his time or any other does. As the opening line says, this is about a betrayal. Strangely enough, the last line of the sonnet ends with a word that is the very essence of betrayal. The sonnet ends with the word, lie. This would cause one to expect to get an explanation of the betrayal between the first and last lines. This appears to be a story of both love and betrayal. In the†¦show more content†¦In the second, line is questions whether he wants the spirit to show that he despises his love. He has wanted her for a long time and he is in misery without her, he is in this deep misery and the only thing he has is his despise for begging. The third quatrain is different from the first two in its format. The first line is indented and the other three are not. This would cause one to think that this line is set apart for a reason. The first two words say why, it is an exclamation to wake up. It is meant to stand out much like a mother coming into a childs room and yelling wake up very early in the morning. Here, the narrator is telling Virtue within himself to awake. He wants to do the right thing. He realizes that although this girl is beautiful, he does not love her and he must let her go. It is not fair to hold on to someone in a relationship or in the words of the first quatrain, keep someone a slave to you, if you do not love them. This is a commentary from over four hundred years ago that is still true in relationships today. Today, people will date or stay together in an unhealthy relationship for stupid reasons or superficial reasons and either one or both of the people do not love the other. The last couplet, the closing lines of the sonnet, also tell the story of relationships today. In the beginning of the relationship he thought that he may have been in love with her.